The Play Off-bound Cleveland Indians can scupper the Minnesota Twins chances of making the Wild Card spots by beating them in their midweek games, before the Indians host the Chicago White Sox to see out the regular season ahead of the Play Offs.
The Houston Astros, also safely into the Play Offs, face midweek games with the Texas Rangers, before fixtures with the Boston Red Sox at the weekend. The Red Sox are the other side from the American League who have guaranteed their Play Off place, and host the Toronto Blue Jays before the weekend games.
The New York Yankees have already secured a Wild Card place ahead of hosting the Tampa Bay Rays in the week, before welcoming the Toronto Blue Jays at the weekend. Elsewhere, the Minnesota Twins need wins against the Cleveland Indians and Detroit Tigers to try and secure the final Wild Card spot in the American League.
The Los Angeles Dodgers will be in the Play Offs and finish their regular season against the San Diego Padres and the Colorado Rockies, with the Rockies very much in the hunt for a Play Off or Wild Card place.
The Washington Nationals are also guaranteed to be in the Play Offs and close their regular season against the Philadelphia Phillies before weekend fixtures with the Pittsburgh Pirates.
The Chicago Cubs will need wins at Wild Card-chasing St Louis Cardinals and at home against the Cincinnati Reds to secure their Play Off place. Any slip ups can allow the Arizona Diamondbacks in to pinch that last place, with the Diamondbacks hosting the San Francisco Giants before travelling to the Kansas City Royals.
The Colorado Rockies will be desperate for wins when they welcome the Miami Marlins, but face that tough weekend trip to the Los Angeles Dodgers.
The Chicago Cubs are finishing the season well and should have enough momentum to finish off the St Louis Cardinals and beat the Cincinnati Reds to secure their Play Off place.
The Minnesota Twins, who need the wins, could spark a surprise at the Cleveland Indians, with the Indians already qualified for the Play Offs. The Twins are then sure to beat the Detroit Tigers in their weekend games to secure that last Wild Card place.